What does increased capillary permeability lead to in the context of edema?

Increased capillary permeability leads to fluid accumulation in the interstitial spaces, which is a key contributor to edema. When the capillary walls become more permeable, they allow not only water but also proteins and other solutes to pass through more easily. This change can result in a higher concentration of solutes in the interstitial fluid, which draws more water out of the bloodstream and into the tissues.

As fluid continues to leak out due to the increased permeability, it accumulates, leading to swelling in the affected areas. This process is particularly relevant in various pathological conditions such as inflammation and allergic reactions, where increased capillary permeability is a common feature. Therefore, the relationship between increased capillary permeability and fluid accumulation is fundamental to understanding how edema forms in the body.