What is the #1 X-linked gene disorder worldwide?

The most prevalent X-linked gene disorder worldwide is G6PD Deficiency. This genetic disorder affects the enzyme glucose-6-phosphate dehydrogenase, which plays a critical role in the pentose phosphate pathway, important for protecting red blood cells from oxidative damage. G6PD deficiency can lead to hemolytic anemia, particularly in response to certain medications, infections, or dietary factors, such as the consumption of fava beans, which can precipitate further health complications.

The reason G6PD Deficiency holds the title of the most common X-linked disorder is largely due to its high carrier frequency, especially in certain populations around the world, including those of African, Mediterranean, and Asian descent. In contrast, while conditions like Hemophilia A, Duchenne Muscular Dystrophy, and Color Blindness are notable X-linked disorders, they do not have the same level of global prevalence as G6PD Deficiency. Thus, its status as the most common X-linked genetic condition is supported by both its wide occurrence and its impact on global health.