What is the most common chromosome disorder?

Trisomy 21, commonly known as Down Syndrome, is recognized as the most prevalent chromosomal disorder in humans. This condition occurs due to the presence of an extra copy of chromosome 21, resulting in a total of three copies rather than the usual two. The occurrence of this extra chromosome leads to a range of developmental and physical characteristics associated with Down Syndrome, including intellectual disability, distinct facial features, and an increased risk of certain medical conditions.

The prevalence of Trisomy 21 is approximately 1 in 700 births, making it the most frequently diagnosed chromosomal condition. This widespread nature is attributed to factors such as maternal age, as the likelihood of having a child with Down Syndrome increases with maternal age.

In contrast, other listed syndromes, such as Turner Syndrome and Klinefelter Syndrome, have lower prevalence rates. Turner Syndrome affects approximately 1 in 2,500 female births and results from the absence of one chromosome X. Klinefelter Syndrome, occurring in males and characterized by an extra X chromosome, affects about 1 in 1,000 male births. Trisomy 16 is a less compatible condition that often results in miscarriage, making it even less common in live births. Thus, Tris