What progressive condition is characterized by degeneration of the basal ganglia?

Parkinson's Disease is characterized by the progressive degeneration of the basal ganglia, which is a group of nuclei in the brain responsible for coordinating movement and regulating various motor functions. This condition specifically affects the dopaminergic neurons in the substantia nigra, a part of the basal ganglia. The loss of these neurons leads to a decrease in dopamine levels, resulting in the hallmark symptoms of Parkinson's, such as tremors, rigidity, and bradykinesia.

The degeneration within the basal ganglia affects the control of involuntary and voluntary movements, leading to the characteristic motor symptoms associated with the disease. Over time, the condition can also impact cognitive functions and overall quality of life, making it a progressive neurological disorder.