Where is the Amyloid precursor protein (APP) gene located?

The Amyloid precursor protein (APP) gene is located on the long arm of chromosome 21, specifically at the region designated as 21q21. The significance of this location becomes particularly evident in the context of certain neurological conditions, such as Alzheimer's disease. Mutations in the APP gene can lead to the production of abnormal amyloid-beta peptides, which aggregate to form plaques that are characteristic of Alzheimer's pathology.

Understanding the chromosomal location of APP is crucial for comprehending its role in hereditary forms of Alzheimer's disease, particularly those associated with down syndrome, as individuals with this condition have an extra copy of chromosome 21 and are at an increased risk for developing Alzheimer's. This knowledge serves as a foundational aspect of studying molecular genetics and pathophysiology related to neurodegenerative conditions.