Which cells produce autoantibodies that are involved in Myasthenia gravis?

In the context of Myasthenia gravis, B-cells play a critical role in the disease's pathophysiology. Myasthenia gravis is characterized by the production of autoantibodies that specifically target acetylcholine receptors at the neuromuscular junction. This interaction between autoantibodies and acetylcholine receptors disrupts normal communication between nerves and muscles, leading to the muscle weakness associated with the condition.

B-cells are a type of white blood cell that is essential for the immune response, and they are responsible for producing antibodies. When triggered by specific antigens, B-cells differentiate into plasma cells, which then produce and secrete these autoantibodies. In Myasthenia gravis, these autoantibodies block and eventually destroy the acetylcholine receptors, which contributes to the clinical symptoms experienced by patients.

Understanding the role of B-cells helps in grasping the autoimmune aspect of Myasthenia gravis and underscores the importance of antibody-mediated processes in the disease.