Who is more likely to exhibit G6PD Deficiency?

G6PD deficiency is an X-linked recessive genetic disorder, which means that the gene responsible for this deficiency is located on the X chromosome. Since males have one X and one Y chromosome (XY), any mutation on their single X chromosome will lead to the expression of the deficiency. In contrast, females have two X chromosomes (XX). For a female to exhibit G6PD deficiency, she must inherit the mutated gene from both parents, making it less common for females to express the condition.

Therefore, individuals who are male are more likely to exhibit G6PD deficiency due to their single X chromosome being at risk. In populations where the deficiency is more common, such as those of African, Mediterranean, or Asian descent, it is predominantly observed in males, highlighting the impact of genetics and inheritance patterns. Understanding the mechanism of inheritance and the implications for males versus females is crucial in the study of genetic disorders like G6PD deficiency.